The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain

The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identi...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188581/
https://www.ncbi.nlm.nih.gov/pubmed/3104529
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description The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamus and pons. CD4- specific mRNA was detected in all three subareas and in the hippocampus, while other subareas were negative. The CD4+ cells were negative with anti-T cell antibodies (anti-CD2 and anti-CD8), as well as with antimonocyte antibodies (M-M 522 and M-M 42).
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spelling pubmed-21885812008-04-17 The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain J Exp Med Articles The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamus and pons. CD4- specific mRNA was detected in all three subareas and in the hippocampus, while other subareas were negative. The CD4+ cells were negative with anti-T cell antibodies (anti-CD2 and anti-CD8), as well as with antimonocyte antibodies (M-M 522 and M-M 42). The Rockefeller University Press 1987-04-01 /pmc/articles/PMC2188581/ /pubmed/3104529 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain
title The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain
title_full The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain
title_fullStr The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain
title_full_unstemmed The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain
title_short The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain
title_sort cellular receptor (cd4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188581/
https://www.ncbi.nlm.nih.gov/pubmed/3104529

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