The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes

We have isolated a cDNA encoding the 84-kD subunit of NFIV. Tryptic peptide sequences were identified within the coding sequences, confirming its proper identity. The primary sequence of the protein is identical to that of the large subunit of the Ku autoantigen. A missing NFIV peptide sequence was...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188621/
https://www.ncbi.nlm.nih.gov/pubmed/2212941
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collection PubMed
description We have isolated a cDNA encoding the 84-kD subunit of NFIV. Tryptic peptide sequences were identified within the coding sequences, confirming its proper identity. The primary sequence of the protein is identical to that of the large subunit of the Ku autoantigen. A missing NFIV peptide sequence was identified within the sequence of the small subunit of Ku. In addition, the proteins are identical in immunological aspects. We suggest that the Ku and NFIV proteins are identical. This connection adds new biochemical data to our knowledge of the Ku autoantigen.
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spelling pubmed-21886212008-04-17 The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes J Exp Med Articles We have isolated a cDNA encoding the 84-kD subunit of NFIV. Tryptic peptide sequences were identified within the coding sequences, confirming its proper identity. The primary sequence of the protein is identical to that of the large subunit of the Ku autoantigen. A missing NFIV peptide sequence was identified within the sequence of the small subunit of Ku. In addition, the proteins are identical in immunological aspects. We suggest that the Ku and NFIV proteins are identical. This connection adds new biochemical data to our knowledge of the Ku autoantigen. The Rockefeller University Press 1990-10-01 /pmc/articles/PMC2188621/ /pubmed/2212941 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes
title The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes
title_full The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes
title_fullStr The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes
title_full_unstemmed The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes
title_short The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes
title_sort autoantigen ku is indistinguishable from nf iv, a protein forming multimeric protein-dna complexes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188621/
https://www.ncbi.nlm.nih.gov/pubmed/2212941

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