High hepatic natural killer cell activity in murine lupus

This study demonstrates a profound elevation of NK activity, as measured by cytotoxicity to YAC-1 targets in a 4-h incubation 51Cr- release assay, of freshly isolated hepatic NPC from both MRL/lpr and (NZB X NZW)F1 mice. This marked increase was not observed in splenic or peripheral blood NK. The he...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188627/
https://www.ncbi.nlm.nih.gov/pubmed/3598462
_version_ 1782146452770783232
collection PubMed
description This study demonstrates a profound elevation of NK activity, as measured by cytotoxicity to YAC-1 targets in a 4-h incubation 51Cr- release assay, of freshly isolated hepatic NPC from both MRL/lpr and (NZB X NZW)F1 mice. This marked increase was not observed in splenic or peripheral blood NK. The hepatic NK were nonadherent, radioresistant, Ly-1-,2-, and AGM1+. Furthermore, biologic response modifiers can further augment hepatic NK activity in these autoimmune strains.
format Text
id pubmed-2188627
institution National Center for Biotechnology Information
language English
publishDate 1987
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21886272008-04-17 High hepatic natural killer cell activity in murine lupus J Exp Med Articles This study demonstrates a profound elevation of NK activity, as measured by cytotoxicity to YAC-1 targets in a 4-h incubation 51Cr- release assay, of freshly isolated hepatic NPC from both MRL/lpr and (NZB X NZW)F1 mice. This marked increase was not observed in splenic or peripheral blood NK. The hepatic NK were nonadherent, radioresistant, Ly-1-,2-, and AGM1+. Furthermore, biologic response modifiers can further augment hepatic NK activity in these autoimmune strains. The Rockefeller University Press 1987-07-01 /pmc/articles/PMC2188627/ /pubmed/3598462 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
High hepatic natural killer cell activity in murine lupus
title High hepatic natural killer cell activity in murine lupus
title_full High hepatic natural killer cell activity in murine lupus
title_fullStr High hepatic natural killer cell activity in murine lupus
title_full_unstemmed High hepatic natural killer cell activity in murine lupus
title_short High hepatic natural killer cell activity in murine lupus
title_sort high hepatic natural killer cell activity in murine lupus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188627/
https://www.ncbi.nlm.nih.gov/pubmed/3598462

Ejemplares similares