Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer

Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to e...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188649/
https://www.ncbi.nlm.nih.gov/pubmed/3298525
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collection PubMed
description Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.
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spelling pubmed-21886492008-04-17 Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer J Exp Med Articles Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time. The Rockefeller University Press 1987-07-01 /pmc/articles/PMC2188649/ /pubmed/3298525 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer
title Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer
title_full Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer
title_fullStr Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer
title_full_unstemmed Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer
title_short Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer
title_sort expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188649/
https://www.ncbi.nlm.nih.gov/pubmed/3298525

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