Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors

The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombina...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188665/
https://www.ncbi.nlm.nih.gov/pubmed/2172437
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description The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombinant TNF-alpha on U937 and HEC were effectively inhibited by Htr-5 and Utr-1, and to a greater extent by a combination of both mAbs. These observations indicate that TNF interaction with antigenically different components of membrane receptors (p55 and p75) represents a crucial step in transduction of signals for TNF toxicity against U937 and TNF activation of HEC functions.
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spelling pubmed-21886652008-04-17 Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors J Exp Med Articles The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endothelial cell (HEC) functions. Actions of recombinant TNF-alpha on U937 and HEC were effectively inhibited by Htr-5 and Utr-1, and to a greater extent by a combination of both mAbs. These observations indicate that TNF interaction with antigenically different components of membrane receptors (p55 and p75) represents a crucial step in transduction of signals for TNF toxicity against U937 and TNF activation of HEC functions. The Rockefeller University Press 1990-11-01 /pmc/articles/PMC2188665/ /pubmed/2172437 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
title Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
title_full Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
title_fullStr Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
title_full_unstemmed Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
title_short Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
title_sort binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188665/
https://www.ncbi.nlm.nih.gov/pubmed/2172437

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