CD4+ cytolytic T cell clone confers protection against murine malaria

A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, p...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188671/
https://www.ncbi.nlm.nih.gov/pubmed/2146361
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description A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-gamma and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.
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spelling pubmed-21886712008-04-17 CD4+ cytolytic T cell clone confers protection against murine malaria J Exp Med Articles A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-gamma and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge. The Rockefeller University Press 1990-11-01 /pmc/articles/PMC2188671/ /pubmed/2146361 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
CD4+ cytolytic T cell clone confers protection against murine malaria
title CD4+ cytolytic T cell clone confers protection against murine malaria
title_full CD4+ cytolytic T cell clone confers protection against murine malaria
title_fullStr CD4+ cytolytic T cell clone confers protection against murine malaria
title_full_unstemmed CD4+ cytolytic T cell clone confers protection against murine malaria
title_short CD4+ cytolytic T cell clone confers protection against murine malaria
title_sort cd4+ cytolytic t cell clone confers protection against murine malaria
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188671/
https://www.ncbi.nlm.nih.gov/pubmed/2146361

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