Development of Ly-1+ B cells in immunodeficient CBA/N mice

Spleen cells from CBA/N mice developing a systemic autoimmune disease after daily injection of CsA during an autologous bone marrow reconstitution were transferred into unmanipulated syngeneic recipients. Adoptive transfer allowed the development of Ly-1+ B cells, which shared Mac-1 differentiation...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188699/
https://www.ncbi.nlm.nih.gov/pubmed/3305762
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description Spleen cells from CBA/N mice developing a systemic autoimmune disease after daily injection of CsA during an autologous bone marrow reconstitution were transferred into unmanipulated syngeneic recipients. Adoptive transfer allowed the development of Ly-1+ B cells, which shared Mac-1 differentiation antigen expression with the myelomonocytic lineage. Interestingly, expansion of formerly absent Ly- 1+ B cells was paralleled by a severe reduction in common, Ly-1-, B cell development in the recipient. We conclude that precursors for Ly- 1+ B lineage do exist in CBA/N mice.
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spelling pubmed-21886992008-04-17 Development of Ly-1+ B cells in immunodeficient CBA/N mice J Exp Med Articles Spleen cells from CBA/N mice developing a systemic autoimmune disease after daily injection of CsA during an autologous bone marrow reconstitution were transferred into unmanipulated syngeneic recipients. Adoptive transfer allowed the development of Ly-1+ B cells, which shared Mac-1 differentiation antigen expression with the myelomonocytic lineage. Interestingly, expansion of formerly absent Ly- 1+ B cells was paralleled by a severe reduction in common, Ly-1-, B cell development in the recipient. We conclude that precursors for Ly- 1+ B lineage do exist in CBA/N mice. The Rockefeller University Press 1987-09-01 /pmc/articles/PMC2188699/ /pubmed/3305762 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Development of Ly-1+ B cells in immunodeficient CBA/N mice
title Development of Ly-1+ B cells in immunodeficient CBA/N mice
title_full Development of Ly-1+ B cells in immunodeficient CBA/N mice
title_fullStr Development of Ly-1+ B cells in immunodeficient CBA/N mice
title_full_unstemmed Development of Ly-1+ B cells in immunodeficient CBA/N mice
title_short Development of Ly-1+ B cells in immunodeficient CBA/N mice
title_sort development of ly-1+ b cells in immunodeficient cba/n mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188699/
https://www.ncbi.nlm.nih.gov/pubmed/3305762

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