Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection

A sensitive radioimmunoassay was used for monitoring serum levels of endogenous cachectin/tumor necrosis factor alpha (TNF) in 10 renal transplant recipients. Acute allograft rejections were associated with marked elevations of circulating TNF. The peak levels of TNF (median 140 pg/ml) were in the s...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188737/
https://www.ncbi.nlm.nih.gov/pubmed/3309124
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description A sensitive radioimmunoassay was used for monitoring serum levels of endogenous cachectin/tumor necrosis factor alpha (TNF) in 10 renal transplant recipients. Acute allograft rejections were associated with marked elevations of circulating TNF. The peak levels of TNF (median 140 pg/ml) were in the same concentration range as previously reported in parasitic infections. The results show that the release of TNF into circulation is an early event in renal allograft rejection and that raised levels of TNF in man can also be induced by noninfectious stimuli.
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spelling pubmed-21887372008-04-17 Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection J Exp Med Articles A sensitive radioimmunoassay was used for monitoring serum levels of endogenous cachectin/tumor necrosis factor alpha (TNF) in 10 renal transplant recipients. Acute allograft rejections were associated with marked elevations of circulating TNF. The peak levels of TNF (median 140 pg/ml) were in the same concentration range as previously reported in parasitic infections. The results show that the release of TNF into circulation is an early event in renal allograft rejection and that raised levels of TNF in man can also be induced by noninfectious stimuli. The Rockefeller University Press 1987-10-01 /pmc/articles/PMC2188737/ /pubmed/3309124 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection
title Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection
title_full Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection
title_fullStr Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection
title_full_unstemmed Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection
title_short Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection
title_sort raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188737/
https://www.ncbi.nlm.nih.gov/pubmed/3309124

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