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Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells
Rabbit antibodies to hsp58 (P1), the human homologue of the Escherichia coli stress protein groEL, react specifically in indirect immunofluorescence and complement-dependent microcytoxicity experiments with a cell surface antigen expressed constitutively by T cell lines bearing gamma/delta receptors...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1990
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188754/ https://www.ncbi.nlm.nih.gov/pubmed/1979591 |
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collection | PubMed |
description | Rabbit antibodies to hsp58 (P1), the human homologue of the Escherichia coli stress protein groEL, react specifically in indirect immunofluorescence and complement-dependent microcytoxicity experiments with a cell surface antigen expressed constitutively by T cell lines bearing gamma/delta receptors. This anti-hsp58-reactive antigen is not demonstrable on T cells that express alpha/beta receptors or on various cells that lack T cell receptors. Certain evidence was obtained to suggest that the target antigen on the surface of gamma/delta T cells is a approximately 77-kD protein distinct from intracellular hsp58 and known members of the hsp70 stress protein family. While the exact nature and significance of this anti-hsp58-reactive protein remain to be determined, these data may help to clarify the roles of groEL- related stress proteins and gamma/delta cells that recognize groEL homologous in immunologic defense against infection and in autoimmune disease. |
format | Text |
id | pubmed-2188754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21887542008-04-17 Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells J Exp Med Articles Rabbit antibodies to hsp58 (P1), the human homologue of the Escherichia coli stress protein groEL, react specifically in indirect immunofluorescence and complement-dependent microcytoxicity experiments with a cell surface antigen expressed constitutively by T cell lines bearing gamma/delta receptors. This anti-hsp58-reactive antigen is not demonstrable on T cells that express alpha/beta receptors or on various cells that lack T cell receptors. Certain evidence was obtained to suggest that the target antigen on the surface of gamma/delta T cells is a approximately 77-kD protein distinct from intracellular hsp58 and known members of the hsp70 stress protein family. While the exact nature and significance of this anti-hsp58-reactive protein remain to be determined, these data may help to clarify the roles of groEL- related stress proteins and gamma/delta cells that recognize groEL homologous in immunologic defense against infection and in autoimmune disease. The Rockefeller University Press 1990-12-01 /pmc/articles/PMC2188754/ /pubmed/1979591 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells |
title | Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells |
title_full | Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells |
title_fullStr | Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells |
title_full_unstemmed | Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells |
title_short | Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells |
title_sort | constitutive expression of a groel-related protein on the surface of human gamma/delta cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188754/ https://www.ncbi.nlm.nih.gov/pubmed/1979591 |