Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias

Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor alpha (RAR alpha) locus. Investi...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1990
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188762/
https://www.ncbi.nlm.nih.gov/pubmed/2175343
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description Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor alpha (RAR alpha) locus. Investigation of 20 APLs and a large series of other neoplastic patients and normal controls revealed RAR alpha gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RAR alpha gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes.
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spelling pubmed-21887622008-04-17 Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias J Exp Med Articles Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor alpha (RAR alpha) locus. Investigation of 20 APLs and a large series of other neoplastic patients and normal controls revealed RAR alpha gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RAR alpha gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes. The Rockefeller University Press 1990-12-01 /pmc/articles/PMC2188762/ /pubmed/2175343 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
title Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
title_full Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
title_fullStr Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
title_full_unstemmed Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
title_short Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
title_sort rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188762/
https://www.ncbi.nlm.nih.gov/pubmed/2175343

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