Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets

We found that three tumor patients treated with mouse mAbs have T cells that recognize processed mouse Ig on autologous APC in a class II- restricted fashion, and we have shown that mouse mAbs directed against various cell surface molecules can be used as antigens to focus these T cells on an MHC cl...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188824/
https://www.ncbi.nlm.nih.gov/pubmed/2450158
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collection PubMed
description We found that three tumor patients treated with mouse mAbs have T cells that recognize processed mouse Ig on autologous APC in a class II- restricted fashion, and we have shown that mouse mAbs directed against various cell surface molecules can be used as antigens to focus these T cells on an MHC class II-positive target of choice.
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spelling pubmed-21888242008-04-17 Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets J Exp Med Articles We found that three tumor patients treated with mouse mAbs have T cells that recognize processed mouse Ig on autologous APC in a class II- restricted fashion, and we have shown that mouse mAbs directed against various cell surface molecules can be used as antigens to focus these T cells on an MHC class II-positive target of choice. The Rockefeller University Press 1988-02-01 /pmc/articles/PMC2188824/ /pubmed/2450158 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
title Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
title_full Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
title_fullStr Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
title_full_unstemmed Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
title_short Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
title_sort antibodies as antigens. the use of mouse monoclonal antibodies to focus human t cells against selected targets
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188824/
https://www.ncbi.nlm.nih.gov/pubmed/2450158

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