A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP

We report the organization of the human genes encoding the complement components C4-binding protein (C4BP), C3b/C4b receptor (CR1), decay accelerating factor (DAF), and C3dg receptor (CR2) within the regulator of complement activation (RCA) gene cluster. Using pulsed field gel electrophoresis analys...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188826/
https://www.ncbi.nlm.nih.gov/pubmed/2450163
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collection PubMed
description We report the organization of the human genes encoding the complement components C4-binding protein (C4BP), C3b/C4b receptor (CR1), decay accelerating factor (DAF), and C3dg receptor (CR2) within the regulator of complement activation (RCA) gene cluster. Using pulsed field gel electrophoresis analysis these genes have been physically linked and aligned as CR1-CR2-DAF-C4BP in an 800-kb DNA segment. The very tight linkage between the CR1 and the C4BP loci, contrasted with the relative long DNA distance between these genes, suggests the existence of mechanisms interfering with recombination within the RCA gene cluster.
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spelling pubmed-21888262008-04-17 A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP J Exp Med Articles We report the organization of the human genes encoding the complement components C4-binding protein (C4BP), C3b/C4b receptor (CR1), decay accelerating factor (DAF), and C3dg receptor (CR2) within the regulator of complement activation (RCA) gene cluster. Using pulsed field gel electrophoresis analysis these genes have been physically linked and aligned as CR1-CR2-DAF-C4BP in an 800-kb DNA segment. The very tight linkage between the CR1 and the C4BP loci, contrasted with the relative long DNA distance between these genes, suggests the existence of mechanisms interfering with recombination within the RCA gene cluster. The Rockefeller University Press 1988-02-01 /pmc/articles/PMC2188826/ /pubmed/2450163 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP
title A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP
title_full A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP
title_fullStr A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP
title_full_unstemmed A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP
title_short A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP
title_sort physical map of the human regulator of complement activation gene cluster linking the complement genes cr1, cr2, daf, and c4bp
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188826/
https://www.ncbi.nlm.nih.gov/pubmed/2450163

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