A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor

This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188863/
https://www.ncbi.nlm.nih.gov/pubmed/3258004
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collection PubMed
description This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells by approximately 3 d. Unlike their mammalian counterpart, TCR1+ cells constitute a relatively large subpopulation of peripheral T cells in mature chickens. These results suggest a phylogenetically important role for this receptor in T cell development and function.
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spelling pubmed-21888632008-04-17 A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor J Exp Med Articles This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells by approximately 3 d. Unlike their mammalian counterpart, TCR1+ cells constitute a relatively large subpopulation of peripheral T cells in mature chickens. These results suggest a phylogenetically important role for this receptor in T cell development and function. The Rockefeller University Press 1988-02-01 /pmc/articles/PMC2188863/ /pubmed/3258004 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor
title A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor
title_full A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor
title_fullStr A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor
title_full_unstemmed A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor
title_short A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor
title_sort large subpopulation of avian t cells express a homologue of the mammalian t gamma/delta receptor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188863/
https://www.ncbi.nlm.nih.gov/pubmed/3258004

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