Thymic lymphoma induction by the AKT8 murine retrovirus

The directly transforming murine retrovirus, AKT8, was isolated from a spontaneous AKR thymoma and carries the cell-derived viral oncogene, akt. We have now shown that this virus produces thymic lymphomas after inoculation of susceptible mouse strains. The presence of the AKT8 genome in the DNA of t...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188879/
https://www.ncbi.nlm.nih.gov/pubmed/2832508
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collection PubMed
description The directly transforming murine retrovirus, AKT8, was isolated from a spontaneous AKR thymoma and carries the cell-derived viral oncogene, akt. We have now shown that this virus produces thymic lymphomas after inoculation of susceptible mouse strains. The presence of the AKT8 genome in the DNA of the virus-induced tumors was demonstrated by Southern blotting using an akt-specific probe. These results establish the in vivo pathogenicity of the AKT8 virus and its akt oncogene, and imply a potential role for the cellular akt proto-oncogene in tumor development.
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spelling pubmed-21888792008-04-17 Thymic lymphoma induction by the AKT8 murine retrovirus J Exp Med Articles The directly transforming murine retrovirus, AKT8, was isolated from a spontaneous AKR thymoma and carries the cell-derived viral oncogene, akt. We have now shown that this virus produces thymic lymphomas after inoculation of susceptible mouse strains. The presence of the AKT8 genome in the DNA of the virus-induced tumors was demonstrated by Southern blotting using an akt-specific probe. These results establish the in vivo pathogenicity of the AKT8 virus and its akt oncogene, and imply a potential role for the cellular akt proto-oncogene in tumor development. The Rockefeller University Press 1988-03-01 /pmc/articles/PMC2188879/ /pubmed/2832508 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Thymic lymphoma induction by the AKT8 murine retrovirus
title Thymic lymphoma induction by the AKT8 murine retrovirus
title_full Thymic lymphoma induction by the AKT8 murine retrovirus
title_fullStr Thymic lymphoma induction by the AKT8 murine retrovirus
title_full_unstemmed Thymic lymphoma induction by the AKT8 murine retrovirus
title_short Thymic lymphoma induction by the AKT8 murine retrovirus
title_sort thymic lymphoma induction by the akt8 murine retrovirus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188879/
https://www.ncbi.nlm.nih.gov/pubmed/2832508

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