A human inhibitor of tumor necrosis factor alpha

Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188924/
https://www.ncbi.nlm.nih.gov/pubmed/2833558
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description Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of a family of negative feedback-regulating molecules interfering with cytokines actions.
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spelling pubmed-21889242008-04-17 A human inhibitor of tumor necrosis factor alpha J Exp Med Articles Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of a family of negative feedback-regulating molecules interfering with cytokines actions. The Rockefeller University Press 1988-04-01 /pmc/articles/PMC2188924/ /pubmed/2833558 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A human inhibitor of tumor necrosis factor alpha
title A human inhibitor of tumor necrosis factor alpha
title_full A human inhibitor of tumor necrosis factor alpha
title_fullStr A human inhibitor of tumor necrosis factor alpha
title_full_unstemmed A human inhibitor of tumor necrosis factor alpha
title_short A human inhibitor of tumor necrosis factor alpha
title_sort human inhibitor of tumor necrosis factor alpha
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188924/
https://www.ncbi.nlm.nih.gov/pubmed/2833558

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