Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor

To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortali...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188949/
https://www.ncbi.nlm.nih.gov/pubmed/3259257
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collection PubMed
description To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg).
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spelling pubmed-21889492008-04-17 Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor J Exp Med Articles To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg). The Rockefeller University Press 1988-05-01 /pmc/articles/PMC2188949/ /pubmed/3259257 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor
title Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor
title_full Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor
title_fullStr Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor
title_full_unstemmed Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor
title_short Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor
title_sort adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188949/
https://www.ncbi.nlm.nih.gov/pubmed/3259257

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