Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice

Eicosanoids have been implicated in the pathogenesis of autoimmune diseases. In this study, peritoneal macrophages from autoimmune-prone mice were examined for their capacity to produce proinflammatory 5- lipoxygenase metabolites. The results indicate that enhanced production of leukotriene C4 is a...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188998/
https://www.ncbi.nlm.nih.gov/pubmed/3137306
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collection PubMed
description Eicosanoids have been implicated in the pathogenesis of autoimmune diseases. In this study, peritoneal macrophages from autoimmune-prone mice were examined for their capacity to produce proinflammatory 5- lipoxygenase metabolites. The results indicate that enhanced production of leukotriene C4 is a common feature of murine autoimmunity and suggest further that aberrations in 5-lipoxygenase activity may play a role in the development of lupus.
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spelling pubmed-21889982008-04-17 Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice J Exp Med Articles Eicosanoids have been implicated in the pathogenesis of autoimmune diseases. In this study, peritoneal macrophages from autoimmune-prone mice were examined for their capacity to produce proinflammatory 5- lipoxygenase metabolites. The results indicate that enhanced production of leukotriene C4 is a common feature of murine autoimmunity and suggest further that aberrations in 5-lipoxygenase activity may play a role in the development of lupus. The Rockefeller University Press 1988-08-01 /pmc/articles/PMC2188998/ /pubmed/3137306 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice
title Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice
title_full Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice
title_fullStr Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice
title_full_unstemmed Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice
title_short Aberrant production of leukotriene C4 by macrophages from autoimmune- prone mice
title_sort aberrant production of leukotriene c4 by macrophages from autoimmune- prone mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188998/
https://www.ncbi.nlm.nih.gov/pubmed/3137306

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