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Induction of arthritis in monkeys by immunization with type II collagen
Immunization of two cynomolugus and three rhesus monkeys with purified type II collagen resulted in the development of polyarthritis. Arthritis first became clinically apparent 7 wk after primary immunization and persisted for 16 mo. Radiologic examination of the limbs demonstrated soft tissue swell...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1988
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189004/ https://www.ncbi.nlm.nih.gov/pubmed/3411292 |
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collection | PubMed |
description | Immunization of two cynomolugus and three rhesus monkeys with purified type II collagen resulted in the development of polyarthritis. Arthritis first became clinically apparent 7 wk after primary immunization and persisted for 16 mo. Radiologic examination of the limbs demonstrated soft tissue swelling with severe joint destruction including loss of cartilage and bone. Involved joints eventually became ankylosed with permanent loss of some motion. All of the monkeys developed a response to the immunizing collagen as determined by ELISA of serum for antibodies. Arthritis was associated with weight loss and constitutional symptoms, including lethargy and refusal to eat. One monkey became so debilitated that it was necessary to euthanize it. Histologic examination of the joints showed synovial hypertrophy with pannus formation. A control monkey immunized with type I collagen suffered no apparent ill effects. |
format | Text |
id | pubmed-2189004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1988 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21890042008-04-17 Induction of arthritis in monkeys by immunization with type II collagen J Exp Med Articles Immunization of two cynomolugus and three rhesus monkeys with purified type II collagen resulted in the development of polyarthritis. Arthritis first became clinically apparent 7 wk after primary immunization and persisted for 16 mo. Radiologic examination of the limbs demonstrated soft tissue swelling with severe joint destruction including loss of cartilage and bone. Involved joints eventually became ankylosed with permanent loss of some motion. All of the monkeys developed a response to the immunizing collagen as determined by ELISA of serum for antibodies. Arthritis was associated with weight loss and constitutional symptoms, including lethargy and refusal to eat. One monkey became so debilitated that it was necessary to euthanize it. Histologic examination of the joints showed synovial hypertrophy with pannus formation. A control monkey immunized with type I collagen suffered no apparent ill effects. The Rockefeller University Press 1988-08-01 /pmc/articles/PMC2189004/ /pubmed/3411292 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Induction of arthritis in monkeys by immunization with type II collagen |
title | Induction of arthritis in monkeys by immunization with type II collagen |
title_full | Induction of arthritis in monkeys by immunization with type II collagen |
title_fullStr | Induction of arthritis in monkeys by immunization with type II collagen |
title_full_unstemmed | Induction of arthritis in monkeys by immunization with type II collagen |
title_short | Induction of arthritis in monkeys by immunization with type II collagen |
title_sort | induction of arthritis in monkeys by immunization with type ii collagen |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189004/ https://www.ncbi.nlm.nih.gov/pubmed/3411292 |