Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis

The genomic organization of the human MHC was examined in multiple examples of six different supratypes using pulsed field electrophoresis (PFGE) after digestion of genomic DNA with infrequency cutting restriction endonucleases. Differences in restriction fragment length and band intensity were show...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189045/
https://www.ncbi.nlm.nih.gov/pubmed/3171479
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description The genomic organization of the human MHC was examined in multiple examples of six different supratypes using pulsed field electrophoresis (PFGE) after digestion of genomic DNA with infrequency cutting restriction endonucleases. Differences in restriction fragment length and band intensity were shown to be specific for each supratype. Mapping of the MHC revealed that each supratype contains previously undescribed deletions and insertions between HLA B and DQ regions.
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spelling pubmed-21890452008-04-17 Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis J Exp Med Articles The genomic organization of the human MHC was examined in multiple examples of six different supratypes using pulsed field electrophoresis (PFGE) after digestion of genomic DNA with infrequency cutting restriction endonucleases. Differences in restriction fragment length and band intensity were shown to be specific for each supratype. Mapping of the MHC revealed that each supratype contains previously undescribed deletions and insertions between HLA B and DQ regions. The Rockefeller University Press 1988-09-01 /pmc/articles/PMC2189045/ /pubmed/3171479 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis
title Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis
title_full Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis
title_fullStr Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis
title_full_unstemmed Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis
title_short Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis
title_sort extensive deletions and insertions in different mhc supratypes detected by pusled field gel electrophoresis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189045/
https://www.ncbi.nlm.nih.gov/pubmed/3171479

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