A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion

We find that a fraction of Ly-1+2- inducer T cell clones inhibits differentiation of memory B cells into IgG-secreting plaque-forming cells. Inhibition of secondary antibody responses was not the result of induction of Ly-2+ T suppressors. Instead, inducer cells directly inactivated B cells, requiri...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1985
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189061/
https://www.ncbi.nlm.nih.gov/pubmed/2580039
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collection PubMed
description We find that a fraction of Ly-1+2- inducer T cell clones inhibits differentiation of memory B cells into IgG-secreting plaque-forming cells. Inhibition of secondary antibody responses was not the result of induction of Ly-2+ T suppressors. Instead, inducer cells directly inactivated B cells, requiring an antigen bridge as well as identity at the major histocompatibility complex (I-A) locus. The interaction between the inducer T cell clone and hapten-specific B memory cells results in an early proliferative response and subsequent failure of B cells to secrete antibody in response to T helper cell signals. Possible mechanisms for this novel type of B cell inactivation are explored.
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spelling pubmed-21890612008-04-17 A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion J Exp Med Articles We find that a fraction of Ly-1+2- inducer T cell clones inhibits differentiation of memory B cells into IgG-secreting plaque-forming cells. Inhibition of secondary antibody responses was not the result of induction of Ly-2+ T suppressors. Instead, inducer cells directly inactivated B cells, requiring an antigen bridge as well as identity at the major histocompatibility complex (I-A) locus. The interaction between the inducer T cell clone and hapten-specific B memory cells results in an early proliferative response and subsequent failure of B cells to secrete antibody in response to T helper cell signals. Possible mechanisms for this novel type of B cell inactivation are explored. The Rockefeller University Press 1985-04-01 /pmc/articles/PMC2189061/ /pubmed/2580039 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion
title A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion
title_full A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion
title_fullStr A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion
title_full_unstemmed A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion
title_short A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion
title_sort subset of ly-1 inducer t cell clones activates b cell proliferation but directly inhibits subsequent igg secretion
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189061/
https://www.ncbi.nlm.nih.gov/pubmed/2580039

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