Identification of CD2-/CD3+ T cells in fetal human tissue

From 1 to 23% of fetal human spleen or thymus cells (from the 20th to 24th week of gestation) were found to display a previously unrecognized CD2-/CD3+ phenotype. IL-2-dependent, long-term clones of CD2-/3+ T cells did not react with a panel of anti-CD2 mAbs and did not form rosettes with sheep eryt...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189098/
https://www.ncbi.nlm.nih.gov/pubmed/2903216
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collection PubMed
description From 1 to 23% of fetal human spleen or thymus cells (from the 20th to 24th week of gestation) were found to display a previously unrecognized CD2-/CD3+ phenotype. IL-2-dependent, long-term clones of CD2-/3+ T cells did not react with a panel of anti-CD2 mAbs and did not form rosettes with sheep erythrocytes. These results show that (a) significant numbers of CD2-/3+ T cells are present in fetal human spleen and/or thymus; and (b) in contrast to the widely accepted view, expression of CD2 is not a prerequisite for the expression of the CD3 molecular complex on human T cells.
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spelling pubmed-21890982008-04-17 Identification of CD2-/CD3+ T cells in fetal human tissue J Exp Med Articles From 1 to 23% of fetal human spleen or thymus cells (from the 20th to 24th week of gestation) were found to display a previously unrecognized CD2-/CD3+ phenotype. IL-2-dependent, long-term clones of CD2-/3+ T cells did not react with a panel of anti-CD2 mAbs and did not form rosettes with sheep erythrocytes. These results show that (a) significant numbers of CD2-/3+ T cells are present in fetal human spleen and/or thymus; and (b) in contrast to the widely accepted view, expression of CD2 is not a prerequisite for the expression of the CD3 molecular complex on human T cells. The Rockefeller University Press 1988-11-01 /pmc/articles/PMC2189098/ /pubmed/2903216 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Identification of CD2-/CD3+ T cells in fetal human tissue
title Identification of CD2-/CD3+ T cells in fetal human tissue
title_full Identification of CD2-/CD3+ T cells in fetal human tissue
title_fullStr Identification of CD2-/CD3+ T cells in fetal human tissue
title_full_unstemmed Identification of CD2-/CD3+ T cells in fetal human tissue
title_short Identification of CD2-/CD3+ T cells in fetal human tissue
title_sort identification of cd2-/cd3+ t cells in fetal human tissue
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189098/
https://www.ncbi.nlm.nih.gov/pubmed/2903216

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