Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity

Using a panel of antibodies specific for H and L chain variable region subgroups, a panel of human monoclonal cold agglutinin (CA) and rheumatoid factor (RF) autoantibodies were analyzed. The vast majority of the two types of autoantibodies utilized VkIII L chains, many of which probably derive from...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189130/
https://www.ncbi.nlm.nih.gov/pubmed/3143801
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collection PubMed
description Using a panel of antibodies specific for H and L chain variable region subgroups, a panel of human monoclonal cold agglutinin (CA) and rheumatoid factor (RF) autoantibodies were analyzed. The vast majority of the two types of autoantibodies utilized VkIII L chains, many of which probably derive from the Humkv325 gene. However, while most RFs (77%) utilized VHI H chains, all the CAs used VHII subgroup H chains. These results are consistent with a model of autoantibody generation, wherein binding specificity is H chain defined in a set of antibodies that use a multipotential L chain.
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spelling pubmed-21891302008-04-17 Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity J Exp Med Articles Using a panel of antibodies specific for H and L chain variable region subgroups, a panel of human monoclonal cold agglutinin (CA) and rheumatoid factor (RF) autoantibodies were analyzed. The vast majority of the two types of autoantibodies utilized VkIII L chains, many of which probably derive from the Humkv325 gene. However, while most RFs (77%) utilized VHI H chains, all the CAs used VHII subgroup H chains. These results are consistent with a model of autoantibody generation, wherein binding specificity is H chain defined in a set of antibodies that use a multipotential L chain. The Rockefeller University Press 1988-12-01 /pmc/articles/PMC2189130/ /pubmed/3143801 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity
title Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity
title_full Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity
title_fullStr Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity
title_full_unstemmed Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity
title_short Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity
title_sort distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189130/
https://www.ncbi.nlm.nih.gov/pubmed/3143801

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