Antibody-mediated enhancement of calcium permeability in cardiac myocytes

Our study shows that antibodies, specific to the ADP/ATP carrier of the inner mitochondrial membrane, crossreact with the cell surface of cardiac myocytes, where the calcium channel seems to be the antigenic determinant. The antibodies enhanced the calcium current and suppressed its inactivation. Af...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189146/
https://www.ncbi.nlm.nih.gov/pubmed/2848919
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collection PubMed
description Our study shows that antibodies, specific to the ADP/ATP carrier of the inner mitochondrial membrane, crossreact with the cell surface of cardiac myocytes, where the calcium channel seems to be the antigenic determinant. The antibodies enhanced the calcium current and suppressed its inactivation. Affinity-purified antibodies (IgG) exhibit an acute cytotoxic effect, which required extracellular calcium and was prevented by calcium channel blockers. Our findings suggest that antibody-mediated cytotoxicity results secondary to calcium overload caused by enhanced cellular calcium permeability, requiring no complement-dependent process.
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spelling pubmed-21891462008-04-17 Antibody-mediated enhancement of calcium permeability in cardiac myocytes J Exp Med Articles Our study shows that antibodies, specific to the ADP/ATP carrier of the inner mitochondrial membrane, crossreact with the cell surface of cardiac myocytes, where the calcium channel seems to be the antigenic determinant. The antibodies enhanced the calcium current and suppressed its inactivation. Affinity-purified antibodies (IgG) exhibit an acute cytotoxic effect, which required extracellular calcium and was prevented by calcium channel blockers. Our findings suggest that antibody-mediated cytotoxicity results secondary to calcium overload caused by enhanced cellular calcium permeability, requiring no complement-dependent process. The Rockefeller University Press 1988-12-01 /pmc/articles/PMC2189146/ /pubmed/2848919 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Antibody-mediated enhancement of calcium permeability in cardiac myocytes
title Antibody-mediated enhancement of calcium permeability in cardiac myocytes
title_full Antibody-mediated enhancement of calcium permeability in cardiac myocytes
title_fullStr Antibody-mediated enhancement of calcium permeability in cardiac myocytes
title_full_unstemmed Antibody-mediated enhancement of calcium permeability in cardiac myocytes
title_short Antibody-mediated enhancement of calcium permeability in cardiac myocytes
title_sort antibody-mediated enhancement of calcium permeability in cardiac myocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189146/
https://www.ncbi.nlm.nih.gov/pubmed/2848919

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