Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone

A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V beta 1 gene element was shown to express two different TCR alpha/beta heterodimers. Antipeptide antisera specific for TCR C beta 1 and C beta 2 peptides each immunoprecipitated distinct disulfide-link...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189151/
https://www.ncbi.nlm.nih.gov/pubmed/2848922
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description A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V beta 1 gene element was shown to express two different TCR alpha/beta heterodimers. Antipeptide antisera specific for TCR C beta 1 and C beta 2 peptides each immunoprecipitated distinct disulfide-linked cell surface heterodimers. The clone was derived from immunized allogeneic chimeric mice, and displayed multiple Ia specificities, including the ability to recognize antigen in association with both I-Ek and I-Es Ia molecules, as well as alloreactivity to the I-Eb molecule. It will be important to determine whether each receptor contributes independently to the overall specificity of the clone.
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spelling pubmed-21891512008-04-17 Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone J Exp Med Articles A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V beta 1 gene element was shown to express two different TCR alpha/beta heterodimers. Antipeptide antisera specific for TCR C beta 1 and C beta 2 peptides each immunoprecipitated distinct disulfide-linked cell surface heterodimers. The clone was derived from immunized allogeneic chimeric mice, and displayed multiple Ia specificities, including the ability to recognize antigen in association with both I-Ek and I-Es Ia molecules, as well as alloreactivity to the I-Eb molecule. It will be important to determine whether each receptor contributes independently to the overall specificity of the clone. The Rockefeller University Press 1988-12-01 /pmc/articles/PMC2189151/ /pubmed/2848922 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone
title Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone
title_full Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone
title_fullStr Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone
title_full_unstemmed Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone
title_short Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone
title_sort expression of two distinct t cell receptor alpha/beta heterodimers by an antigen-specific t cell clone
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189151/
https://www.ncbi.nlm.nih.gov/pubmed/2848922

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