Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189170/
https://www.ncbi.nlm.nih.gov/pubmed/2909659
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collection PubMed
description Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans- encoded HLA-DQ alpha/beta heterodimer.
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spelling pubmed-21891702008-04-17 Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer J Exp Med Articles Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans- encoded HLA-DQ alpha/beta heterodimer. The Rockefeller University Press 1989-01-01 /pmc/articles/PMC2189170/ /pubmed/2909659 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
title Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
title_full Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
title_fullStr Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
title_full_unstemmed Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
title_short Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
title_sort evidence for a primary association of celiac disease to a particular hla-dq alpha/beta heterodimer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189170/
https://www.ncbi.nlm.nih.gov/pubmed/2909659

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