Selective loss of beta 2-microglobulin mRNA in human colon carcinoma

Expression of MHC class I antigens requires the intracellular assembly of HLA-A,B,C H chains and beta 2-microglobulin (beta 2m). We have investigated the expression of free H chain, beta 2m, and their mRNAs in tissue sections of colon carcinomas that were defective for the native two-chain molecule....

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189171/
https://www.ncbi.nlm.nih.gov/pubmed/2642530
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collection PubMed
description Expression of MHC class I antigens requires the intracellular assembly of HLA-A,B,C H chains and beta 2-microglobulin (beta 2m). We have investigated the expression of free H chain, beta 2m, and their mRNAs in tissue sections of colon carcinomas that were defective for the native two-chain molecule. In all of these tumors, beta 2m protein and mRNA were found to be completely absent from the neoplastic cells, whereas free H chains and their respective mRNAs were present in abundance in the tumor cell cytoplasm. The selective abrogation of beta 2m expression represents a unique mechanism leading to a complete loss of class I antigen surface expression in vivo.
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spelling pubmed-21891712008-04-17 Selective loss of beta 2-microglobulin mRNA in human colon carcinoma J Exp Med Articles Expression of MHC class I antigens requires the intracellular assembly of HLA-A,B,C H chains and beta 2-microglobulin (beta 2m). We have investigated the expression of free H chain, beta 2m, and their mRNAs in tissue sections of colon carcinomas that were defective for the native two-chain molecule. In all of these tumors, beta 2m protein and mRNA were found to be completely absent from the neoplastic cells, whereas free H chains and their respective mRNAs were present in abundance in the tumor cell cytoplasm. The selective abrogation of beta 2m expression represents a unique mechanism leading to a complete loss of class I antigen surface expression in vivo. The Rockefeller University Press 1989-01-01 /pmc/articles/PMC2189171/ /pubmed/2642530 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Selective loss of beta 2-microglobulin mRNA in human colon carcinoma
title Selective loss of beta 2-microglobulin mRNA in human colon carcinoma
title_full Selective loss of beta 2-microglobulin mRNA in human colon carcinoma
title_fullStr Selective loss of beta 2-microglobulin mRNA in human colon carcinoma
title_full_unstemmed Selective loss of beta 2-microglobulin mRNA in human colon carcinoma
title_short Selective loss of beta 2-microglobulin mRNA in human colon carcinoma
title_sort selective loss of beta 2-microglobulin mrna in human colon carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189171/
https://www.ncbi.nlm.nih.gov/pubmed/2642530

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