Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)

Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189178/
https://www.ncbi.nlm.nih.gov/pubmed/2521242
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description Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the cloning and expression of a cDNA for this new growth factor. The predicted mature protein is a cationic cysteine-rich polypeptide of 14 kD without significant homology to previously sequenced proteins.
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spelling pubmed-21891782008-04-17 Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40) J Exp Med Articles Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the cloning and expression of a cDNA for this new growth factor. The predicted mature protein is a cationic cysteine-rich polypeptide of 14 kD without significant homology to previously sequenced proteins. The Rockefeller University Press 1989-01-01 /pmc/articles/PMC2189178/ /pubmed/2521242 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)
title Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)
title_full Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)
title_fullStr Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)
title_full_unstemmed Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)
title_short Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)
title_sort cloning and characterization of a cdna for a new mouse t cell growth factor (p40)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189178/
https://www.ncbi.nlm.nih.gov/pubmed/2521242

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