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Active and latent forms of transforming growth factor beta activity in synovial effusions

We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta- like activity in synovial effusions by four criteria: (a) TGF-beta receptor co...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189180/
https://www.ncbi.nlm.nih.gov/pubmed/2909658
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description We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta- like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK- 49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.
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spelling pubmed-21891802008-04-17 Active and latent forms of transforming growth factor beta activity in synovial effusions J Exp Med Articles We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta- like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK- 49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form. The Rockefeller University Press 1989-01-01 /pmc/articles/PMC2189180/ /pubmed/2909658 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Active and latent forms of transforming growth factor beta activity in synovial effusions
title Active and latent forms of transforming growth factor beta activity in synovial effusions
title_full Active and latent forms of transforming growth factor beta activity in synovial effusions
title_fullStr Active and latent forms of transforming growth factor beta activity in synovial effusions
title_full_unstemmed Active and latent forms of transforming growth factor beta activity in synovial effusions
title_short Active and latent forms of transforming growth factor beta activity in synovial effusions
title_sort active and latent forms of transforming growth factor beta activity in synovial effusions
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189180/
https://www.ncbi.nlm.nih.gov/pubmed/2909658