Role of the thymus in natural tolerance to an autologous protein antigen

C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5- deficient hosts repopulated with lymphoid cells from thymectomized C5- deficient mice grafted with...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189186/
https://www.ncbi.nlm.nih.gov/pubmed/2909657
_version_ 1782146583395041280
collection PubMed
description C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5- deficient hosts repopulated with lymphoid cells from thymectomized C5- deficient mice grafted with C5-sufficient thymus also failed to respond to immunization with C5, thus showing that the state of tolerance can be adoptively transferred. These results demonstrate that natural tolerance to self-protein antigen is "learned" in the thymus.
format Text
id pubmed-2189186
institution National Center for Biotechnology Information
language English
publishDate 1989
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21891862008-04-17 Role of the thymus in natural tolerance to an autologous protein antigen J Exp Med Articles C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5- deficient hosts repopulated with lymphoid cells from thymectomized C5- deficient mice grafted with C5-sufficient thymus also failed to respond to immunization with C5, thus showing that the state of tolerance can be adoptively transferred. These results demonstrate that natural tolerance to self-protein antigen is "learned" in the thymus. The Rockefeller University Press 1989-01-01 /pmc/articles/PMC2189186/ /pubmed/2909657 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Role of the thymus in natural tolerance to an autologous protein antigen
title Role of the thymus in natural tolerance to an autologous protein antigen
title_full Role of the thymus in natural tolerance to an autologous protein antigen
title_fullStr Role of the thymus in natural tolerance to an autologous protein antigen
title_full_unstemmed Role of the thymus in natural tolerance to an autologous protein antigen
title_short Role of the thymus in natural tolerance to an autologous protein antigen
title_sort role of the thymus in natural tolerance to an autologous protein antigen
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189186/
https://www.ncbi.nlm.nih.gov/pubmed/2909657

Ejemplares similares