Cargando…

H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system

Infection of the peripheral nervous system was studied after inoculation of HSV into the flank skin of H-2 congenic mice. The amount of virus recovered from the sensory ganglia varied significantly between the mouse strains tested. Differences became apparent 7 d after infection, at which time the s...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189235/
https://www.ncbi.nlm.nih.gov/pubmed/2538554
_version_ 1782146594841296896
collection PubMed
description Infection of the peripheral nervous system was studied after inoculation of HSV into the flank skin of H-2 congenic mice. The amount of virus recovered from the sensory ganglia varied significantly between the mouse strains tested. Differences became apparent 7 d after infection, at which time the severity of disease in H-2k mice was two to three orders of magnitude greater than that in H-2d animals. The association of the H-2k haplotype with impaired ability to clear HSV from the nervous system is the first clear demonstration that genes within the MHC can influence the severity of primary herpetic infection, in spite of numerous studies on genetic resistance to this disease.
format Text
id pubmed-2189235
institution National Center for Biotechnology Information
language English
publishDate 1989
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21892352008-04-17 H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system J Exp Med Articles Infection of the peripheral nervous system was studied after inoculation of HSV into the flank skin of H-2 congenic mice. The amount of virus recovered from the sensory ganglia varied significantly between the mouse strains tested. Differences became apparent 7 d after infection, at which time the severity of disease in H-2k mice was two to three orders of magnitude greater than that in H-2d animals. The association of the H-2k haplotype with impaired ability to clear HSV from the nervous system is the first clear demonstration that genes within the MHC can influence the severity of primary herpetic infection, in spite of numerous studies on genetic resistance to this disease. The Rockefeller University Press 1989-04-01 /pmc/articles/PMC2189235/ /pubmed/2538554 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system
title H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system
title_full H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system
title_fullStr H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system
title_full_unstemmed H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system
title_short H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system
title_sort h-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189235/
https://www.ncbi.nlm.nih.gov/pubmed/2538554