L3T4 antigen expression by hemopoietic precursor cells

L3T4 (CD4) is expressed on immature hematopoietic cells. Sorting bone marrow cells on the basis of their expression of this antigen produces populations of cells that are markedly enriched for multipotential stem cells (CFU-s) and for myeloid precursors (CFU-c). We believe that L3T4 is transiently e...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189248/
https://www.ncbi.nlm.nih.gov/pubmed/2784487
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collection PubMed
description L3T4 (CD4) is expressed on immature hematopoietic cells. Sorting bone marrow cells on the basis of their expression of this antigen produces populations of cells that are markedly enriched for multipotential stem cells (CFU-s) and for myeloid precursors (CFU-c). We believe that L3T4 is transiently expressed by most, if not all, hematopoietic precursors early in their maturation. We suggest that the expression of CD4 molecules on the surface of immature precursors is required for their interaction with Ia bearing cells within the hemopoietic inductive microenvironment(s) of the marrow and thymus.
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spelling pubmed-21892482008-04-17 L3T4 antigen expression by hemopoietic precursor cells J Exp Med Articles L3T4 (CD4) is expressed on immature hematopoietic cells. Sorting bone marrow cells on the basis of their expression of this antigen produces populations of cells that are markedly enriched for multipotential stem cells (CFU-s) and for myeloid precursors (CFU-c). We believe that L3T4 is transiently expressed by most, if not all, hematopoietic precursors early in their maturation. We suggest that the expression of CD4 molecules on the surface of immature precursors is required for their interaction with Ia bearing cells within the hemopoietic inductive microenvironment(s) of the marrow and thymus. The Rockefeller University Press 1989-04-01 /pmc/articles/PMC2189248/ /pubmed/2784487 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
L3T4 antigen expression by hemopoietic precursor cells
title L3T4 antigen expression by hemopoietic precursor cells
title_full L3T4 antigen expression by hemopoietic precursor cells
title_fullStr L3T4 antigen expression by hemopoietic precursor cells
title_full_unstemmed L3T4 antigen expression by hemopoietic precursor cells
title_short L3T4 antigen expression by hemopoietic precursor cells
title_sort l3t4 antigen expression by hemopoietic precursor cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189248/
https://www.ncbi.nlm.nih.gov/pubmed/2784487

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