Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression

Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These include changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor producti...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189254/
https://www.ncbi.nlm.nih.gov/pubmed/2494294
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collection PubMed
description Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These include changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor production, and chromosomal stability. Further, there are spontaneous progressive alterations in vitro in the karyotype and antigenic profile of the transformed cells. Cytogenetic analyses suggest that alterations of chromosome 21 may play an early and pivotal role in the development of transformed proximal tubule cells.
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spelling pubmed-21892542008-04-17 Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression J Exp Med Articles Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These include changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor production, and chromosomal stability. Further, there are spontaneous progressive alterations in vitro in the karyotype and antigenic profile of the transformed cells. Cytogenetic analyses suggest that alterations of chromosome 21 may play an early and pivotal role in the development of transformed proximal tubule cells. The Rockefeller University Press 1989-03-01 /pmc/articles/PMC2189254/ /pubmed/2494294 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression
title Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression
title_full Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression
title_fullStr Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression
title_full_unstemmed Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression
title_short Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression
title_sort transformation of human kidney proximal tubule cells by ras-containing retroviruses. implications for tumor progression
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189254/
https://www.ncbi.nlm.nih.gov/pubmed/2494294

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