Induction of classical transplantation tolerance in the adult

Transplantation tolerance across histoincompatibilities in multiple non- H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state w...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189271/
https://www.ncbi.nlm.nih.gov/pubmed/2647894
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description Transplantation tolerance across histoincompatibilities in multiple non- H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cells. Tolerance was associated with partial donor chimerism to various degrees. Tolerance to minor transplantation antigens induced in this manner was restricted to recipient-type MHC. The possibility was raised that tolerance resulted, at least in part, from clonal anergy rather than deletion.
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spelling pubmed-21892712008-04-17 Induction of classical transplantation tolerance in the adult J Exp Med Articles Transplantation tolerance across histoincompatibilities in multiple non- H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cells. Tolerance was associated with partial donor chimerism to various degrees. Tolerance to minor transplantation antigens induced in this manner was restricted to recipient-type MHC. The possibility was raised that tolerance resulted, at least in part, from clonal anergy rather than deletion. The Rockefeller University Press 1989-03-01 /pmc/articles/PMC2189271/ /pubmed/2647894 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Induction of classical transplantation tolerance in the adult
title Induction of classical transplantation tolerance in the adult
title_full Induction of classical transplantation tolerance in the adult
title_fullStr Induction of classical transplantation tolerance in the adult
title_full_unstemmed Induction of classical transplantation tolerance in the adult
title_short Induction of classical transplantation tolerance in the adult
title_sort induction of classical transplantation tolerance in the adult
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189271/
https://www.ncbi.nlm.nih.gov/pubmed/2647894

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