Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related

We have analyzed expression patterns of 7 lymphokine mRNAs by Northern blot analyses in 19 different human T cell clones derived from patients with adult T cell leukemia. However, we were not able to reveal particular combinations of lymphokine production that allowed classification of human T cells...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189311/
https://www.ncbi.nlm.nih.gov/pubmed/2469771
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collection PubMed
description We have analyzed expression patterns of 7 lymphokine mRNAs by Northern blot analyses in 19 different human T cell clones derived from patients with adult T cell leukemia. However, we were not able to reveal particular combinations of lymphokine production that allowed classification of human T cells. Especially, four clonally related leukemic lines that were established independently from the same patient with adult T cell leukemia expressed different combinations of lymphokine mRNAs, indicating that the expression of various lymphokines is not fixed but rather variable even among progenies of a single T cell clone.
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spelling pubmed-21893112008-04-17 Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related J Exp Med Articles We have analyzed expression patterns of 7 lymphokine mRNAs by Northern blot analyses in 19 different human T cell clones derived from patients with adult T cell leukemia. However, we were not able to reveal particular combinations of lymphokine production that allowed classification of human T cells. Especially, four clonally related leukemic lines that were established independently from the same patient with adult T cell leukemia expressed different combinations of lymphokine mRNAs, indicating that the expression of various lymphokines is not fixed but rather variable even among progenies of a single T cell clone. The Rockefeller University Press 1989-05-01 /pmc/articles/PMC2189311/ /pubmed/2469771 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related
title Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related
title_full Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related
title_fullStr Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related
title_full_unstemmed Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related
title_short Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related
title_sort expression of different combinations of interleukins by human t cell leukemic cell lines that are clonally related
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189311/
https://www.ncbi.nlm.nih.gov/pubmed/2469771

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