Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain

CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. H...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189325/
https://www.ncbi.nlm.nih.gov/pubmed/2541219
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collection PubMed
description CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.
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spelling pubmed-21893252008-04-17 Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain J Exp Med Articles CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy. The Rockefeller University Press 1989-05-01 /pmc/articles/PMC2189325/ /pubmed/2541219 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain
title Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain
title_full Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain
title_fullStr Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain
title_full_unstemmed Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain
title_short Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain
title_sort cytotoxic t lymphocytes specific for self tumor immunoglobulin express t cell receptor delta chain
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189325/
https://www.ncbi.nlm.nih.gov/pubmed/2541219

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