Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein

We have previously shown that tobacco glycoprotein (TGP), a polyphenol- rich glycoprotein isolated from tobacco or from cigarette smoke, affects the immune system. In this study we show that TGP induces human PBL and adherent cells to produce IL-1 alpha and IL-1 beta. Two peaks of IL-1 activity were...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189364/
https://www.ncbi.nlm.nih.gov/pubmed/2787383
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collection PubMed
description We have previously shown that tobacco glycoprotein (TGP), a polyphenol- rich glycoprotein isolated from tobacco or from cigarette smoke, affects the immune system. In this study we show that TGP induces human PBL and adherent cells to produce IL-1 alpha and IL-1 beta. Two peaks of IL-1 activity were observed; one at 18-24 h, the second at 4-6 d after initiation of culture. A similar pattern was observed for the steady state level of IL-1 mRNA. These data suggest that the production of IL-1 by cells stimulated with TGP might be a factor in cardiovascular disease associated with cigarette smoking.
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spelling pubmed-21893642008-04-17 Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein J Exp Med Articles We have previously shown that tobacco glycoprotein (TGP), a polyphenol- rich glycoprotein isolated from tobacco or from cigarette smoke, affects the immune system. In this study we show that TGP induces human PBL and adherent cells to produce IL-1 alpha and IL-1 beta. Two peaks of IL-1 activity were observed; one at 18-24 h, the second at 4-6 d after initiation of culture. A similar pattern was observed for the steady state level of IL-1 mRNA. These data suggest that the production of IL-1 by cells stimulated with TGP might be a factor in cardiovascular disease associated with cigarette smoking. The Rockefeller University Press 1989-07-01 /pmc/articles/PMC2189364/ /pubmed/2787383 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein
title Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein
title_full Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein
title_fullStr Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein
title_full_unstemmed Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein
title_short Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein
title_sort two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189364/
https://www.ncbi.nlm.nih.gov/pubmed/2787383

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