Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series

A third allele at the DRB3 locus, DRw52c, represents an intermediate sequence between DRw52a and DRw52b and may have arisen by a gene conversion-like event. The recognition of cells bearing these molecules by a number of alloreactive and antigen-specific DR-restricted T cell clones was analyzed. On...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189422/
https://www.ncbi.nlm.nih.gov/pubmed/2788702
_version_ 1782146638549090304
collection PubMed
description A third allele at the DRB3 locus, DRw52c, represents an intermediate sequence between DRw52a and DRw52b and may have arisen by a gene conversion-like event. The recognition of cells bearing these molecules by a number of alloreactive and antigen-specific DR-restricted T cell clones was analyzed. On the basis of a theoretical model of HLA class II structure, distinct amino acid clusters have been identified as motifs controlling TCR recognition. These are located both in the cleft and in the alpha-helical edge of the MHC class II recognition platform. Motifs shared between two alleles may restrict public T cell clones.
format Text
id pubmed-2189422
institution National Center for Biotechnology Information
language English
publishDate 1989
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21894222008-04-17 Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series J Exp Med Articles A third allele at the DRB3 locus, DRw52c, represents an intermediate sequence between DRw52a and DRw52b and may have arisen by a gene conversion-like event. The recognition of cells bearing these molecules by a number of alloreactive and antigen-specific DR-restricted T cell clones was analyzed. On the basis of a theoretical model of HLA class II structure, distinct amino acid clusters have been identified as motifs controlling TCR recognition. These are located both in the cleft and in the alpha-helical edge of the MHC class II recognition platform. Motifs shared between two alleles may restrict public T cell clones. The Rockefeller University Press 1989-09-01 /pmc/articles/PMC2189422/ /pubmed/2788702 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series
title Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series
title_full Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series
title_fullStr Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series
title_full_unstemmed Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series
title_short Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series
title_sort correlation of structure with t cell responses of the three members of the hla-drw52 allelic series
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189422/
https://www.ncbi.nlm.nih.gov/pubmed/2788702

Ejemplares similares