Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes

Since class I MHC glycoproteins may function by "screening and selecting" degraded proteins, we wished to determine whether very short peptides made within a cell were detected and bound by MHC, and presented for T cell perusal. We show that a 22 amino acid viral sequence containing a Db-r...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189441/
https://www.ncbi.nlm.nih.gov/pubmed/2475568
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collection PubMed
description Since class I MHC glycoproteins may function by "screening and selecting" degraded proteins, we wished to determine whether very short peptides made within a cell were detected and bound by MHC, and presented for T cell perusal. We show that a 22 amino acid viral sequence containing a Db-restricted nonameric CTL epitope is sufficient to direct CTL recognition/lysis of H2b target cells. The mechanism of epitope presentation is by the "natural" endogenous route, and appears to direct lysis as effectively as wild-type virus infection, in which the epitope is part of a 236 residue glycoprotein.
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spelling pubmed-21894412008-04-17 Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes J Exp Med Articles Since class I MHC glycoproteins may function by "screening and selecting" degraded proteins, we wished to determine whether very short peptides made within a cell were detected and bound by MHC, and presented for T cell perusal. We show that a 22 amino acid viral sequence containing a Db-restricted nonameric CTL epitope is sufficient to direct CTL recognition/lysis of H2b target cells. The mechanism of epitope presentation is by the "natural" endogenous route, and appears to direct lysis as effectively as wild-type virus infection, in which the epitope is part of a 236 residue glycoprotein. The Rockefeller University Press 1989-09-01 /pmc/articles/PMC2189441/ /pubmed/2475568 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes
title Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes
title_full Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes
title_fullStr Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes
title_full_unstemmed Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes
title_short Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes
title_sort class i mhc can present an endogenous peptide to cytotoxic t lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189441/
https://www.ncbi.nlm.nih.gov/pubmed/2475568

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