Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells

Lymphocytes isolated from human fetal liver and expanded in vitro in IL- 2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189446/
https://www.ncbi.nlm.nih.gov/pubmed/2527944
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collection PubMed
description Lymphocytes isolated from human fetal liver and expanded in vitro in IL- 2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse targets in lectin-mediated killing assays and to perform classical helper functions. These results add new information necessary for a better understanding of the physiological role of the gamma, delta T cells.
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spelling pubmed-21894462008-04-17 Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells J Exp Med Articles Lymphocytes isolated from human fetal liver and expanded in vitro in IL- 2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse targets in lectin-mediated killing assays and to perform classical helper functions. These results add new information necessary for a better understanding of the physiological role of the gamma, delta T cells. The Rockefeller University Press 1989-09-01 /pmc/articles/PMC2189446/ /pubmed/2527944 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells
title Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells
title_full Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells
title_fullStr Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells
title_full_unstemmed Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells
title_short Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells
title_sort isolation and characterization of (gamma, delta) cd4+ t cell clones derived from human fetal liver cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189446/
https://www.ncbi.nlm.nih.gov/pubmed/2527944

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