Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes

The addition of TGF-beta to cultures of LPS-stimulated murine B cells causes a approximately 10-fold enhancement of IgA production, yet causes a 10-fold decrease in total Ig production. IL-2 and, to a lesser extent, IL-5 synergize with TGF-beta to further enhance IgA production and partially reverse...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189449/
https://www.ncbi.nlm.nih.gov/pubmed/2788703
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collection PubMed
description The addition of TGF-beta to cultures of LPS-stimulated murine B cells causes a approximately 10-fold enhancement of IgA production, yet causes a 10-fold decrease in total Ig production. IL-2 and, to a lesser extent, IL-5 synergize with TGF-beta to further enhance IgA production and partially reverse the inhibition of total Ig production. IgA constitutes only approximately 0.1% of total Ig in LPS-stimulated cultures, but that percentage rises to 15-25% in cultures to which TGF- beta and IL-2 are added. TGF-beta induces a substantial increase in IgA production from sIgA- B cells but inhibits IgA production by sIgA+ cells. This finding suggests that TGF-beta acts as an isotype-specific switch factor for IgA.
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spelling pubmed-21894492008-04-17 Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes J Exp Med Articles The addition of TGF-beta to cultures of LPS-stimulated murine B cells causes a approximately 10-fold enhancement of IgA production, yet causes a 10-fold decrease in total Ig production. IL-2 and, to a lesser extent, IL-5 synergize with TGF-beta to further enhance IgA production and partially reverse the inhibition of total Ig production. IgA constitutes only approximately 0.1% of total Ig in LPS-stimulated cultures, but that percentage rises to 15-25% in cultures to which TGF- beta and IL-2 are added. TGF-beta induces a substantial increase in IgA production from sIgA- B cells but inhibits IgA production by sIgA+ cells. This finding suggests that TGF-beta acts as an isotype-specific switch factor for IgA. The Rockefeller University Press 1989-09-01 /pmc/articles/PMC2189449/ /pubmed/2788703 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
title Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
title_full Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
title_fullStr Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
title_full_unstemmed Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
title_short Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
title_sort transforming growth factor beta specifically enhances iga production by lipopolysaccharide-stimulated murine b lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189449/
https://www.ncbi.nlm.nih.gov/pubmed/2788703

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