The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis

We report that the spirochete B. burgdorferi induces progressive polyarthritis and carditis in mice with severe combined immunodeficiency syndrome (scid) but not in normal C.B-17 mice. The onset and severity of the disease were dependent on (a) the viability; (b) the infectivity; and (c) the dose of...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189455/
https://www.ncbi.nlm.nih.gov/pubmed/2794862
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description We report that the spirochete B. burgdorferi induces progressive polyarthritis and carditis in mice with severe combined immunodeficiency syndrome (scid) but not in normal C.B-17 mice. The onset and severity of the disease were dependent on (a) the viability; (b) the infectivity; and (c) the dose of inoculated B. burgdorferi organisms. Infective spirochetes were isolated from both blood and joints of inoculated scid mice. These findings suggest that B. burgdorferi-induced chronic arthritis and carditis in mice develops independently of lymphocyte function and makes the scid mouse an attractive laboratory model to study the role of the immune system in experimental Lyme Borreliosis.
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spelling pubmed-21894552008-04-17 The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis J Exp Med Articles We report that the spirochete B. burgdorferi induces progressive polyarthritis and carditis in mice with severe combined immunodeficiency syndrome (scid) but not in normal C.B-17 mice. The onset and severity of the disease were dependent on (a) the viability; (b) the infectivity; and (c) the dose of inoculated B. burgdorferi organisms. Infective spirochetes were isolated from both blood and joints of inoculated scid mice. These findings suggest that B. burgdorferi-induced chronic arthritis and carditis in mice develops independently of lymphocyte function and makes the scid mouse an attractive laboratory model to study the role of the immune system in experimental Lyme Borreliosis. The Rockefeller University Press 1989-10-01 /pmc/articles/PMC2189455/ /pubmed/2794862 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis
title The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis
title_full The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis
title_fullStr The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis
title_full_unstemmed The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis
title_short The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis
title_sort severe combined immunodeficiency (scid) mouse. a laboratory model for the analysis of lyme arthritis and carditis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189455/
https://www.ncbi.nlm.nih.gov/pubmed/2794862

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