Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex

Insertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse- field gel electrophoresis. Two independent IDRP systems were detected by analysis of Sfi I- and Sal I-digested human DNA samples using probes for TCR C and V...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189474/
https://www.ncbi.nlm.nih.gov/pubmed/2571667
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collection PubMed
description Insertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse- field gel electrophoresis. Two independent IDRP systems were detected by analysis of Sfi I- and Sal I-digested human DNA samples using probes for TCR C and V region gene segments. The allelic nature of these systems was verified in family studies, and mapping data allowed localization of one area of insertion/deletion among the V gene segments and the other near the C region genes. All but one of 50 individuals tested could be typed for the two allelic systems, and gene frequencies for the two allelic forms were 0.37/0.61 and 0.46/0.54, indicating that these polymorphisms are widespread.
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spelling pubmed-21894742008-04-17 Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex J Exp Med Articles Insertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse- field gel electrophoresis. Two independent IDRP systems were detected by analysis of Sfi I- and Sal I-digested human DNA samples using probes for TCR C and V region gene segments. The allelic nature of these systems was verified in family studies, and mapping data allowed localization of one area of insertion/deletion among the V gene segments and the other near the C region genes. All but one of 50 individuals tested could be typed for the two allelic systems, and gene frequencies for the two allelic forms were 0.37/0.61 and 0.46/0.54, indicating that these polymorphisms are widespread. The Rockefeller University Press 1989-10-01 /pmc/articles/PMC2189474/ /pubmed/2571667 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex
title Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex
title_full Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex
title_fullStr Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex
title_full_unstemmed Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex
title_short Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex
title_sort insertion/deletion-related polymorphisms in the human t cell receptor beta gene complex
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189474/
https://www.ncbi.nlm.nih.gov/pubmed/2571667

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