Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes

In this paper we have shown that extensively purified human B lymphocytes respond to IL-4 treatment with a marked production of IL-6. Addition of anti-mu potentiated the effect of IL-4 on IL-6 production. Other cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189485/
https://www.ncbi.nlm.nih.gov/pubmed/2677211
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collection PubMed
description In this paper we have shown that extensively purified human B lymphocytes respond to IL-4 treatment with a marked production of IL-6. Addition of anti-mu potentiated the effect of IL-4 on IL-6 production. Other cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce IL-6 secretion when given to resting B cells. Although B cells generally also produced TNF-alpha and TNF-beta upon stimulation, IL-4 did not induce TNF secretion and seemingly had a specific effect on IL-6 production.
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spelling pubmed-21894852008-04-17 Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes J Exp Med Articles In this paper we have shown that extensively purified human B lymphocytes respond to IL-4 treatment with a marked production of IL-6. Addition of anti-mu potentiated the effect of IL-4 on IL-6 production. Other cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce IL-6 secretion when given to resting B cells. Although B cells generally also produced TNF-alpha and TNF-beta upon stimulation, IL-4 did not induce TNF secretion and seemingly had a specific effect on IL-6 production. The Rockefeller University Press 1989-10-01 /pmc/articles/PMC2189485/ /pubmed/2677211 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
title Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
title_full Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
title_fullStr Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
title_full_unstemmed Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
title_short Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
title_sort interleukin 4 induces selective production of interleukin 6 from normal human b lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189485/
https://www.ncbi.nlm.nih.gov/pubmed/2677211

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