Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells

rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1989
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189501/
https://www.ncbi.nlm.nih.gov/pubmed/2530302
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collection PubMed
description rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production of IL-4 and IFN-gamma may be significantly influenced by the chronological order of activation of their respective gene.
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spelling pubmed-21895012008-04-17 Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells J Exp Med Articles rIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production of IL-4 and IFN-gamma may be significantly influenced by the chronological order of activation of their respective gene. The Rockefeller University Press 1989-11-01 /pmc/articles/PMC2189501/ /pubmed/2530302 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells
title Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells
title_full Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells
title_fullStr Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells
title_full_unstemmed Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells
title_short Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells
title_sort recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189501/
https://www.ncbi.nlm.nih.gov/pubmed/2530302

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