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Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus
The role of thymic MHC class II-bearing cells in the selection of the TCR repertoire has been investigated in allogeneic radiation bone marrow chimeras. Positive selection of mature CD4+ T lymphocytes expressing the V beta 6+ TCR domain was found to depend upon radioresistant (presumably epithelial)...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1989
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189548/ https://www.ncbi.nlm.nih.gov/pubmed/2511269 |
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collection | PubMed |
description | The role of thymic MHC class II-bearing cells in the selection of the TCR repertoire has been investigated in allogeneic radiation bone marrow chimeras. Positive selection of mature CD4+ T lymphocytes expressing the V beta 6+ TCR domain was found to depend upon radioresistant (presumably epithelial) I-E+ thymic cells. On the other hand, negative selection of CD4+ V beta 6+ cells (which was additionally dependent upon expression of the Mls-1a gene product) was controlled by a radiosensitive I-E+ thymic component (most likely dendritic cells). These data argue in favor of a compartmentalization of positive and negative selection events during T cell development. |
format | Text |
id | pubmed-2189548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1989 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21895482008-04-17 Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus J Exp Med Articles The role of thymic MHC class II-bearing cells in the selection of the TCR repertoire has been investigated in allogeneic radiation bone marrow chimeras. Positive selection of mature CD4+ T lymphocytes expressing the V beta 6+ TCR domain was found to depend upon radioresistant (presumably epithelial) I-E+ thymic cells. On the other hand, negative selection of CD4+ V beta 6+ cells (which was additionally dependent upon expression of the Mls-1a gene product) was controlled by a radiosensitive I-E+ thymic component (most likely dendritic cells). These data argue in favor of a compartmentalization of positive and negative selection events during T cell development. The Rockefeller University Press 1989-12-01 /pmc/articles/PMC2189548/ /pubmed/2511269 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus |
title | Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus |
title_full | Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus |
title_fullStr | Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus |
title_full_unstemmed | Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus |
title_short | Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus |
title_sort | positive and negative selection of t cell receptor v beta domains controlled by distinct cell populations in the thymus |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189548/ https://www.ncbi.nlm.nih.gov/pubmed/2511269 |