Independent association of T cell receptor beta and gamma chains with CD3 in the same cell

We have demonstrated that the PEER cell line, which expresses a CD3- associated TCR gamma chain on the cell surface, synthesizes TCR beta chain intracellularly. A percentage of this TCR beta chain associates with the CD3 complex intracellularly. These results indicate that TCR beta and gamma chains...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189592/
https://www.ncbi.nlm.nih.gov/pubmed/3110356
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collection PubMed
description We have demonstrated that the PEER cell line, which expresses a CD3- associated TCR gamma chain on the cell surface, synthesizes TCR beta chain intracellularly. A percentage of this TCR beta chain associates with the CD3 complex intracellularly. These results indicate that TCR beta and gamma chains can be synthesized by one cell line, and that these chains can independently associate with the CD3 complex. However, the results argue against the formation of TCR beta gamma chain complexes in this cell line.
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spelling pubmed-21895922008-04-17 Independent association of T cell receptor beta and gamma chains with CD3 in the same cell J Exp Med Articles We have demonstrated that the PEER cell line, which expresses a CD3- associated TCR gamma chain on the cell surface, synthesizes TCR beta chain intracellularly. A percentage of this TCR beta chain associates with the CD3 complex intracellularly. These results indicate that TCR beta and gamma chains can be synthesized by one cell line, and that these chains can independently associate with the CD3 complex. However, the results argue against the formation of TCR beta gamma chain complexes in this cell line. The Rockefeller University Press 1987-08-01 /pmc/articles/PMC2189592/ /pubmed/3110356 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Independent association of T cell receptor beta and gamma chains with CD3 in the same cell
title Independent association of T cell receptor beta and gamma chains with CD3 in the same cell
title_full Independent association of T cell receptor beta and gamma chains with CD3 in the same cell
title_fullStr Independent association of T cell receptor beta and gamma chains with CD3 in the same cell
title_full_unstemmed Independent association of T cell receptor beta and gamma chains with CD3 in the same cell
title_short Independent association of T cell receptor beta and gamma chains with CD3 in the same cell
title_sort independent association of t cell receptor beta and gamma chains with cd3 in the same cell
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189592/
https://www.ncbi.nlm.nih.gov/pubmed/3110356

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