A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types

We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase m...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189607/
https://www.ncbi.nlm.nih.gov/pubmed/3036997
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description We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.
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spelling pubmed-21896072008-04-17 A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types J Exp Med Articles We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed. The Rockefeller University Press 1987-08-01 /pmc/articles/PMC2189607/ /pubmed/3036997 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types
title A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types
title_full A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types
title_fullStr A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types
title_full_unstemmed A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types
title_short A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types
title_sort low polymorphic mouse h-2 class i gene from the tla complex is expressed in a broad variety of cell types
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189607/
https://www.ncbi.nlm.nih.gov/pubmed/3036997

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