Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells

A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1 beta antibody in a dose- dependent manner, but not...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189653/
https://www.ncbi.nlm.nih.gov/pubmed/3316474
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collection PubMed
description A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1 beta antibody in a dose- dependent manner, but not by rabbit anti-IL-1 alpha antibody. Culture supernatants of these leukemic cells contained IL-1 activity, which was specifically inhibited by addition of anti-IL-1 beta antibody, and Northern blot analysis detected intracellular IL-1 beta mRNA. These results indicated that autocrine secretion of IL-1 beta was involved in proliferation of some myelogenous leukemic cells.
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spelling pubmed-21896532008-04-17 Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells J Exp Med Articles A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1 beta antibody in a dose- dependent manner, but not by rabbit anti-IL-1 alpha antibody. Culture supernatants of these leukemic cells contained IL-1 activity, which was specifically inhibited by addition of anti-IL-1 beta antibody, and Northern blot analysis detected intracellular IL-1 beta mRNA. These results indicated that autocrine secretion of IL-1 beta was involved in proliferation of some myelogenous leukemic cells. The Rockefeller University Press 1987-11-01 /pmc/articles/PMC2189653/ /pubmed/3316474 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells
title Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells
title_full Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells
title_fullStr Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells
title_full_unstemmed Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells
title_short Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells
title_sort autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189653/
https://www.ncbi.nlm.nih.gov/pubmed/3316474

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