Synthetic peptide vaccine confers protection against murine malaria

A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and m...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1987
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189666/
https://www.ncbi.nlm.nih.gov/pubmed/3316473
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description A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoites.
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spelling pubmed-21896662008-04-17 Synthetic peptide vaccine confers protection against murine malaria J Exp Med Articles A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoites. The Rockefeller University Press 1987-11-01 /pmc/articles/PMC2189666/ /pubmed/3316473 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Synthetic peptide vaccine confers protection against murine malaria
title Synthetic peptide vaccine confers protection against murine malaria
title_full Synthetic peptide vaccine confers protection against murine malaria
title_fullStr Synthetic peptide vaccine confers protection against murine malaria
title_full_unstemmed Synthetic peptide vaccine confers protection against murine malaria
title_short Synthetic peptide vaccine confers protection against murine malaria
title_sort synthetic peptide vaccine confers protection against murine malaria
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189666/
https://www.ncbi.nlm.nih.gov/pubmed/3316473

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