Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice

We examined the effects of treatment with rHuTNF on food consumption and body weight in C3H/HeJ mice. rHuTNF was administered intraperitoneally either by injections of 3, 12, or 24 micrograms twice a day or by implantation of osmotic pumps that released 0.75, 3, or 12 micrograms per day. Dose-depend...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189683/
https://www.ncbi.nlm.nih.gov/pubmed/3385359
_version_ 1782146687741984768
collection PubMed
description We examined the effects of treatment with rHuTNF on food consumption and body weight in C3H/HeJ mice. rHuTNF was administered intraperitoneally either by injections of 3, 12, or 24 micrograms twice a day or by implantation of osmotic pumps that released 0.75, 3, or 12 micrograms per day. Dose-dependent reductions in both food intake and weight were induced by rHuTNF. However, in spite of continued exposure to rHuTNF, the mice developed a resistance to rHuTNF and resumed their pretreatment food intake and weight. Non-immunological factors may play a role in the development of this tolerance, since it developed rapidly and faded within 2 wk of cessation of exposure to rHuTNF.
format Text
id pubmed-2189683
institution National Center for Biotechnology Information
language English
publishDate 1988
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21896832008-04-17 Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice J Exp Med Articles We examined the effects of treatment with rHuTNF on food consumption and body weight in C3H/HeJ mice. rHuTNF was administered intraperitoneally either by injections of 3, 12, or 24 micrograms twice a day or by implantation of osmotic pumps that released 0.75, 3, or 12 micrograms per day. Dose-dependent reductions in both food intake and weight were induced by rHuTNF. However, in spite of continued exposure to rHuTNF, the mice developed a resistance to rHuTNF and resumed their pretreatment food intake and weight. Non-immunological factors may play a role in the development of this tolerance, since it developed rapidly and faded within 2 wk of cessation of exposure to rHuTNF. The Rockefeller University Press 1988-06-01 /pmc/articles/PMC2189683/ /pubmed/3385359 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice
title Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice
title_full Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice
title_fullStr Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice
title_full_unstemmed Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice
title_short Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice
title_sort recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189683/
https://www.ncbi.nlm.nih.gov/pubmed/3385359

Ejemplares similares